Movement
how fit and strong you are
VO₂max is the strongest single reading we track — it predicts all-cause mortality more strongly than smoking or high blood pressure, with no observed ceiling (Mandsager 2018, JAMA Netw Open). Grip strength is a separate marker. The resistance-training sweet spot is a modest 30–60 min/week.
Tier 1
e.g. VO₂max trend
Recovery
how well you sleep & bounce back
~7–8 h, and regularity may matter as much as total (Windred 2024). Heart-rate recovery and HRV are honest but noisy autonomic signals — read as trends, not verdicts. Loud snoring or witnessed apneas → test for sleep apnea; untreated it shortens lives, and it's treatable.
Tier 1
e.g. sleep-regularity index
Fuel
what you eat and drink
The Mediterranean pattern is the most RCT-supported way to eat for the long view (PREDIMED). Enough fiber and protein; less ultra-processed food. On alcohol, the health-optimal dose is zero — we report the evidence and don't moralize about it.
Tier 1
e.g. protein adherence
Biology
what your bloodwork says
ApoB is the headline marker — causal for atherosclerosis, so lower reads better. Plus Lp(a), inflammation (hsCRP), glycemic control (HbA1c), and blood pressure. PhenoAge is computed as a biological-age trend — never a precise number, and labelled Tier 2. No $300 epigenetic "aging clocks."
ApoB · Tier 1
PhenoAge · Tier 2
Environment
the conditions you live in
Weak social connection carries a mortality signal comparable to smoking (Holt-Lunstad 2015). Plus air quality (no safe threshold; modern targets ~5–9 µg/m³ PM2.5), purpose, cognitive engagement, and a calendar of proven age-appropriate screenings.
Tier 1
e.g. screening calendar
read the source
Every citation, in full.
The complete framework — five domains, each target with its peer-reviewed source and its honest tier Tier 1 settled · Tier 4 early, unproven.